| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50448056 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1289501 (CHEMBL3117417) |
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| IC50 | 90±n/a nM |
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| Citation |  El-Subbagh, HI; Hassan, GS; El-Messery, SM; Al-Rashood, ST; Al-Omary, FA; Abulfadl, YS; Shabayek, MI Nonclassical antifolates, part 5. Benzodiazepine analogs as a new class of DHFR inhibitors: synthesis, antitumor testing and molecular modeling study. Eur J Med Chem74:234-45 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR) |
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| Type: | Enzyme |
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| Mol. Mass.: | 21603.71 |
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| Organism: | Bos taurus (Cattle) |
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| Description: | P00376 |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSS
VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF
EVYEKNN
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| BDBM50448056 |
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| n/a |
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| Name | BDBM50448056 |
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| Synonyms: | CHEMBL3115736 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H34N2O6 |
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| Mol. Mass. | 542.6222 |
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| SMILES | COc1cc(C=C2CCCC3C2=Nc2ccccc2N=C3c2cc(OC)c(OC)c(OC)c2)cc(OC)c1OC |w:5.4,c:21,t:12| |
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| Structure | 
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