Reaction Details |
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Target | Glucokinase regulatory protein |
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Ligand | BDBM50447292 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1296098 (CHEMBL3131527) |
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EC50 | 82±n/a nM |
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Citation | Ashton, KS; Andrews, KL; Bryan, MC; Bryan, MC; Chen, J; Chen, K; Chen, M; Chmait, S; Croghan, M; Cupples, R; Fotsch, C; Helmering, J; Jordan, SR; Kurzeja, RJ; Michelsen, K; Pennington, LD; Poon, SF; Sivits, G; Van, G; Vonderfecht, SL; Wahl, RC; Zhang, J; Lloyd, DJ; Hale, C; St Jean, DJ Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept. J Med Chem57:309-24 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glucokinase regulatory protein |
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Name: | Glucokinase regulatory protein |
Synonyms: | GCKR_RAT | Gckr | Glucokinase regulator |
Type: | PROTEIN |
Mol. Mass.: | 68920.17 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_108045 |
Residue: | 627 |
Sequence: | MPGTKRYQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVKLLGQCDAEI
FQEEGQIVPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVS
FNQLMKGLGQKPLYTYLIAGGDRSVVASREQTEDSALHGIEELKKVAAGKKRVVVIGISV
GLSAPFVAGQMDYCMDNTAVFLPVLVGFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQ
EAFVLNPAIGPEGLSGSSRMKGGGATKILLETLLLAAHKTVDQGVVSSQRCLLEILRTFE
RAHQVTYSQSSKIATLMKQVGISLEKKGRVHLVGWQTLGIIAIMDGVECIHTFGADFQDI
RGFLIGDHSDMFNQKDELTNQGPQFTFSQDDFLTSILPSLTETDTVVFIFTLDDNLTEVQ
ALAERVREKCQNIQALVHSTVGQSLPAPLKKLFPSLISITWPLLFFDYEGTYVQKFQREL
STKWVLNTVSTGAHVLLGKILQNHMLDLRIANSKLFWRALAMLQRFSGQSKARCIESLLQ
AIHFPQPLSDDVRAAPISCHVQVAHEKEKVIPTALLSLLLRCSISEAKARLSAASSVCEV
VRSALSGPGQKRSTQALEDPPACGTLN
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BDBM50447292 |
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n/a |
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Name | BDBM50447292 |
Synonyms: | CHEMBL3113979 |
Type | Small organic molecule |
Emp. Form. | C23H30F3N3O4S2 |
Mol. Mass. | 533.627 |
SMILES | C[C@H]1COCCN1C[C@H]1CN(CCN1c1ccc(cc1)[C@@](C)(O)C(F)(F)F)S(=O)(=O)c1cccs1 |r| |
Structure |
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