| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase kappa |
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| Ligand | BDBM50448690 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1297316 (CHEMBL3132281) |
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| IC50 | >200000±n/a nM |
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| Citation |  Mizushina, Y; Suzuki-Fukudome, H; Takeuchi, T; Takemoto, K; Kuriyama, I; Yoshida, H; Kamisuki, S; Sugawara, F Formosusin A, a novel specific inhibitor of mammalian DNA polymeraseß from the fungus Paecilomyces formosus. Bioorg Med Chem22:1070-6 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase kappa |
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| Name: | DNA polymerase kappa |
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| Synonyms: | DINB1 | POLK | POLK_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 98825.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1297316 |
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| Residue: | 870 |
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| Sequence: | MDSTKEKCDSYKDDLLLRMGLNDNKAGMEGLDKEKINKIIMEATKGSRFYGNELKKEKQV
NQRIENMMQQKAQITSQQLRKAQLQVDRFAMELEQSRNLSNTIVHIDMDAFYAAVEMRDN
PELKDKPIAVGSMSMLSTSNYHARRFGVRAAMPGFIAKRLCPQLIIVPPNFDKYRAVSKE
VKEILADYDPNFMAMSLDEAYLNITKHLEERQNWPEDKRRYFIKMGSSVENDNPGKEVNK
LSEHERSISPLLFEESPSDVQPPGDPFQVNFEEQNNPQILQNSVVFGTSAQEVVKEIRFR
IEQKTTLTASAGIAPNTMLAKVCSDKNKPNGQYQILPNRQAVMDFIKDLPIRKVSGIGKV
TEKMLKALGIITCTELYQQRALLSLLFSETSWHYFLHISLGLGSTHLTRDGERKSMSVER
TFSEINKAEEQYSLCQELCSELAQDLQKERLKGRTVTIKLKNVNFEVKTRASTVSSVVST
AEEIFAIAKELLKTEIDADFPHPLRLRLMGVRISSFPNEEDRKHQQRSIIGFLQAGNQAL
SATECTLEKTDKDKFVKPLEMSHKKSFFDKKRSERKWSHQDTFKCEAVNKQSFQTSQPFQ
VLKKKMNENLEISENSDDCQILTCPVCFRAQGCISLEALNKHVDECLDGPSISENFKMFS
CSHVSATKVNKKENVPASSLCEKQDYEAHPKIKEISSVDCIALVDTIDNSSKAESIDALS
NKHSKEECSSLPSKSFNIEHCHQNSSSTVSLENEDVGSFRQEYRQPYLCEVKTGQALVCP
VCNVEQKTSDLTLFNVHVDVCLNKSFIQELRKDKFNPVNQPKESSRSTGSSSGVQKAVTR
TKRPGLMTKYSTSKKIKPNNPKHTLDIFFK
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| BDBM50448690 |
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| n/a |
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| Name | BDBM50448690 |
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| Synonyms: | CHEMBL3127728 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H25NO3 |
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| Mol. Mass. | 291.3853 |
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| SMILES | CCCCC(=O)C=C(C)C=CCCC(=O)N1CCCC1=O |w:6.5,9.8| |
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| Structure | 
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