Reaction Details |
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Target | Neuronal acetylcholine receptor subunit beta-2/beta-4 |
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Ligand | BDBM50006628 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1335312 (CHEMBL3238809) |
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IC50 | 31000±n/a nM |
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Citation | Crestey, F; Jensen, AA; Borch, M; Andreasen, JT; Andersen, J; Balle, T; Kristensen, JL Design, synthesis, and biological evaluation of Erythrina alkaloid analogues as neuronal nicotinic acetylcholine receptor antagonists. J Med Chem56:9673-82 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Neuronal acetylcholine receptor subunit beta-2/beta-4 |
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Name: | Neuronal acetylcholine receptor subunit beta-2/beta-4 |
Synonyms: | Nicotinic acetylcholine receptor alpha-4/beta-2 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of ChEMBL is 1335312 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Neuronal acetylcholine receptor subunit beta-4 |
Synonyms: | ACHB4_MOUSE | Acrb4 | Chrnb4 |
Type: | PROTEIN |
Mol. Mass.: | 55814.93 |
Organism: | Mus musculus |
Description: | ChEMBL_108396 |
Residue: | 495 |
Sequence: | MRGTPLLLVSLFALLQPGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELS
LSQLISVNEREQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNA
DGTYEVSVYTNVIVRSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEI
DMVLKSPTAIMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLII
PCVLITSLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLF
TMVLVTFSIVTTVCVLNVHHRSPSTHTMASWVKECFLHKLPTFLFMKRPGLEVSPARVPH
SSQLHLTTAEATSTSALGPSSPSNLYGNSMYFVNPVPATPKSAVSSHTAGLPRDARLRSS
GRFRQDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVIVCILGTMGL
FLPPLFQIHAPSKGL
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Component 2 |
Name: | Neuronal acetylcholine receptor subunit beta-2 |
Synonyms: | ACHB2_MOUSE | Chrnb2 |
Type: | PROTEIN |
Mol. Mass.: | 57114.19 |
Organism: | Mus musculus |
Description: | ChEMBL_108396 |
Residue: | 501 |
Sequence: | MARCSNSMALLFSFGLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQL
MVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLY
NNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDR
TEIDLVLKSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDITYDFIIRRKPLFYTIN
LIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKY
LMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQR
LRLRRRQREREGAGTLFFREGPAADPCTCFVNPASMQGLAGAFQAEPAAAGLGRSMGPCS
CGLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTIGMFLQP
LFQNYTATTFLHSDHSAPSSK
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BDBM50006628 |
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n/a |
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Name | BDBM50006628 |
Synonyms: | CHEMBL3235504 |
Type | Small organic molecule |
Emp. Form. | C18H25NO2 |
Mol. Mass. | 287.3966 |
SMILES | [H][C@]12CCN3CCc4cc(OC)c(OC)cc4[C@]13CCCC2 |r| |
Structure |
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