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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Diacylglycerol O-acyltransferase 1 | ||
| Ligand | BDBM50009393 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1335973 (CHEMBL3239094) | ||
| IC50 | >10000±n/a nM | ||
| Citation |  Zhou, G; Ting, PC; Wishart, G; Zorn, N; Aslanian, RG; Lin, M; Smith, M; Walker, SS; Cook, J; Van Heek, M; Lachowicz, J Discovery of novel quinoline carboxylic acid series as DGAT1 inhibitors. Bioorg Med Chem Lett24:1790-4 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Diacylglycerol O-acyltransferase 1 | |||
| Name: | Diacylglycerol O-acyltransferase 1 | ||
| Synonyms: | DGAT1_MOUSE | Dgat | Dgat1 | Diacyl Glycerolacyltransferase 1 (DGAT-1) | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 56810.61 | ||
| Organism: | Mus musculus (mouse) | ||
| Description: | In this assay, recombinant mouse DGAT-1 containing an N-terminal His6-epitope tag was produced in the baculovirus expression system. | ||
| Residue: | 498 | ||
| Sequence: |
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| BDBM50009393 | |||
| n/a | |||
| Name | BDBM50009393 | ||
| Synonyms: | CHEMBL3233874 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H27N3O2 | ||
| Mol. Mass. | 437.5329 | ||
| SMILES | OC(=O)C[C@H]1CC[C@@H](CC1)c1ccc(cc1)-c1ccc2nc(Nc3ccccc3)ncc2c1 |r,wU:7.10,wD:4.3,(43.43,-15.9,;43.42,-14.37,;44.75,-13.58,;42.08,-13.61,;40.75,-14.39,;39.41,-13.63,;38.08,-14.41,;38.1,-15.94,;39.44,-16.7,;40.76,-15.93,;36.77,-16.72,;36.78,-18.27,;35.46,-19.05,;34.12,-18.28,;34.1,-16.75,;35.42,-15.97,;32.79,-19.07,;32.81,-20.6,;31.49,-21.38,;30.15,-20.63,;28.82,-21.43,;27.47,-20.69,;26.15,-21.49,;24.8,-20.75,;24.77,-19.21,;23.42,-18.47,;22.11,-19.27,;22.15,-20.82,;23.5,-21.55,;27.43,-19.13,;28.76,-18.33,;30.12,-19.08,;31.45,-18.3,)| | ||
| Structure | 
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