| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM50272612 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1348900 (CHEMBL3271169) |
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| IC50 | 29400±n/a nM |
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| Citation |  Jabeen, F; Oliferenko, PV; Oliferenko, AA; Pillai, GG; Ansari, FL; Hall, CD; Katritzky, AR Dual inhibition of thea-glucosidase and butyrylcholinesterase studied by molecular field topology analysis. Eur J Med Chem80:228-42 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase |
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| Type: | Homotetramer |
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| Mol. Mass.: | 68422.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06276 |
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| Residue: | 602 |
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| Sequence: | MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIP
YAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDC
LYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPG
SHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEI
LLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVY
GAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDV
VGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLER
RDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMT
KLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCV
GL
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| BDBM50272612 |
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| n/a |
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| Name | BDBM50272612 |
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| Synonyms: | 2-(3''-Chlorophenyl)-4-(3'-hydroxyphenyl)-2,3-dihydro-1,5-benzothiazepine | CHEMBL525905 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H16ClNOS |
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| Mol. Mass. | 365.876 |
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| SMILES | Oc1cccc(c1)C1=Nc2ccccc2SC(C1)c1cccc(Cl)c1 |t:8| |
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| Structure | 
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