| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 7 |
|---|
| Ligand | BDBM50022759 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1368985 |
|---|
| EC50 | >10000±n/a nM |
|---|
| Citation |  Turlington, M; Malosh, C; Jacobs, J; Manka, JT; Noetzel, MJ; Vinson, PN; Jadhav, S; Herman, EJ; Lavreysen, H; Mackie, C; Bartolomé-Nebreda, JM; Conde-Ceide, S; Martín-Martín, ML; Tong, HM; López, S; MacDonald, GJ; Steckler, T; Daniels, JS; Weaver, CD; Niswender, CM; Jones, CK; Conn, PJ; Lindsley, CW; Stauffer, SR Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5). J Med Chem57:5620-37 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Metabotropic glutamate receptor 7 |
|---|
| Name: | Metabotropic glutamate receptor 7 |
|---|
| Synonyms: | GRM7_RAT | Gprc1g | Grm7 | Metabotropic glutamate receptor | Metabotropic glutamate receptor 7 (mGlu7) | Mglur7 | mGlu7 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 102244.48 |
|---|
| Organism: | Rattus norvegicus (Rat) |
|---|
| Description: | P35400 |
|---|
| Residue: | 915 |
|---|
| Sequence: | MVQLGKLLRVLTLMKFPCCVLEVLLCVLAAAARGQEMYAPHSIRIEGDVTLGGLFPVHAK
GPSGVPCGDIKRENGIHRLEAMLYALDQINSDPNLLPNVTLGARILDTCSRDTYALEQSL
TFVQALIQKDTSDVRCTNGEPPVFVKPEKVVGVIGASGSSVSIMVANILRLFQIPQISYA
STAPELSDDRRYDFFSRVVPPDSFQAQAMVDIVKALGWNYVSTLASEGSYGEKGVESFTQ
ISKEAGGLCIAQSVRIPQERKDRTIDFDRIIKQLLDTPNSRAVVIFANDEDIKQILAAAK
RADQVGHFLWVGSDSWGSKINPLHQHEDIAEGAITIQPKRATVEGFDAYFTSRTLENNRR
NVWFAEYWEENFNCKLTISGSKKEDTDRKCTGQERIGKDSNYEQEGKVQFVIDAVYAMAH
ALHHMNKDLCADYRGVCPEMEQAGGKKLLKYIRHVNFNGSAGTPVMFNKNGDAPGRYDIF
QYQTTNTTNPGYRLIGQWTDELQLNIEDMQWGKGVREIPSSVCTLPCKPGQRKKTQKGTP
CCWTCEPCDGYQYQFDEMTCQHCPYDQRPNENRTGCQNIPIIKLEWHSPWAVIPVFLAML
GIIATIFVMATFIRYNDTPIVRASGRELSYVLLTGIFLCYIITFLMIAKPDVAVCSFRRV
FLGLGMCISYAALLTKTNRIYRIFEQGKKSVTAPRLISPTSQLAITSSLISVQLLGVFIW
FGVDPPNIIIDYDEHKTMNPEQARGVLKCDITDLQIICSLGYSILLMVTCTVYAIKTRGV
PENFNEAKPIGFTMYTTCIVWLAFIPIFFGTAQSAEKLYIQTTTLTISMNLSASVALGML
YMPKVYIIIFHPELNVQKRKRSFKAVVTAATMSSRLSHKPSDRPNGEAKTELCENVDPNS
PAAKKKYVSYNNLVI
|
|
|
|---|
| BDBM50022759 |
|---|
| n/a |
|---|
| Name | BDBM50022759 |
|---|
| Synonyms: | CHEMBL3298273 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H13FN2O2 |
|---|
| Mol. Mass. | 272.2743 |
|---|
| SMILES | Fc1cccc(COc2ccc3C(=O)NCCc3n2)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
