| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50039134 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1444883 (CHEMBL3380225) |
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| Ki | 544±n/a nM |
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| Citation |  Pati, ML; Abate, C; Contino, M; Ferorelli, S; Luisi, R; Carroccia, L; Niso, M; Berardi, F Deconstruction of 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline moiety to separate P-glycoprotein (P-gp) activity froms2 receptor affinity in mixed P-gp/s2 receptor agents. Eur J Med Chem89:691-700 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 25307.17 |
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| Organism: | Cavia porcellus (Guinea pig) |
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| Description: | Q60492 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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| BDBM50039134 |
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| n/a |
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| Name | BDBM50039134 |
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| Synonyms: | CHEMBL3355368 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H27FN2O |
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| Mol. Mass. | 402.5038 |
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| SMILES | COc1cccc(CNCCCCc2cn(-c3ccc(F)cc3)c3ccccc23)c1 |
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| Structure | 
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