| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
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| Ligand | BDBM50040255 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1443751 (CHEMBL3371724) |
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| Ki | 128±n/a nM |
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| Citation |  Xu, R; Lord, SA; Peterson, RM; Fergason-Cantrell, EA; Lever, JR; Lever, SZ Ether modifications to 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): effects on binding affinity and selectivity for sigma receptors and monoamine transporters. Bioorg Med Chem23:222-30 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent serotonin transporter |
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| Name: | Sodium-dependent serotonin transporter |
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| Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | Htt | SC6A4_MOUSE | Serotonin transporter | Sert | Slc6a4 | Sodium-dependent serotonin transporter | Solute carrier family 6 member 4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 70044.92 |
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| Organism: | MOUSE |
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| Description: | 5-HT Transporter SLC6A4 MOUSE::Q60857 |
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| Residue: | 630 |
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| Sequence: | METTPLNSQKVLSECKDKEDCQENGVLQKGVPTPADKAGPGQISNGYSAVPSTSAGDEAP
HSTPAATTTLVAEIHQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWKKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLALCIMLIFTIIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCILGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVVVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIILGYCIGTSSVICIPIYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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| BDBM50040255 |
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| n/a |
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| Name | BDBM50040255 |
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| Synonyms: | CHEMBL3360023 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H36N2O2 |
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| Mol. Mass. | 444.6083 |
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| SMILES | COc1cc(CCN2CCN(CCCc3ccccc3)CC2)ccc1OCc1ccccc1 |
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| Structure | 
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