| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Inosine-5'-monophosphate dehydrogenase |
|---|
| Ligand | BDBM50040476 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1443968 (CHEMBL3375356) |
|---|
| IC50 | 20±n/a nM |
|---|
| Citation |  Sun, Z; Khan, J; Makowska-Grzyska, M; Zhang, M; Cho, JH; Suebsuwong, C; Vo, P; Gollapalli, DR; Kim, Y; Joachimiak, A; Hedstrom, L; Cuny, GD Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors. J Med Chem57:10544-50 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Inosine-5'-monophosphate dehydrogenase |
|---|
| Name: | Inosine-5'-monophosphate dehydrogenase |
|---|
| Synonyms: | Cgd6_20 protein | IMDH_CRYPV | Inosine-5'-monophosphate dehydrogenase, probable | Inosine-5-monophosphate dehydrogenase (IMPDH) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 43076.80 |
|---|
| Organism: | Cryptosporidium parvum |
|---|
| Description: | Q8T6T2 |
|---|
| Residue: | 400 |
|---|
| Sequence: | MGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAV
GMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNN
IDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIK
SKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSS
VASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYR
GMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLG
SASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK
|
|
|
|---|
| BDBM50040476 |
|---|
| n/a |
|---|
| Name | BDBM50040476 |
|---|
| Synonyms: | CHEMBL3360632 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H14ClN3O4 |
|---|
| Mol. Mass. | 383.785 |
|---|
| SMILES | COc1cc(NC(=O)Cn2ncc3c2c2ccccc2oc3=O)ccc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
