| Reaction Details |
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 | Report a problem with these data |
| Target | Gamma-aminobutyric acid receptor subunit rho-1 |
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| Ligand | BDBM50032955 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1456653 (CHEMBL3370253) |
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| EC50 | 39000±n/a nM |
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| Citation |  Petersen, JG; Sørensen, T; Damgaard, M; Nielsen, B; Jensen, AA; Balle, T; Bergmann, R; Frølund, B Synthesis and pharmacological evaluation of 6-aminonicotinic acid analogues as novel GABA(A) receptor agonists. Eur J Med Chem84:404-16 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gamma-aminobutyric acid receptor subunit rho-1 |
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| Name: | Gamma-aminobutyric acid receptor subunit rho-1 |
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| Synonyms: | GABA receptor rho-1 subunit | GABA-C receptor | GABRR1 | GBRR1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 55892.34 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1456653 |
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| Residue: | 479 |
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| Sequence: | MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPI
LRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTM
TLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRV
QPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTD
ERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSW
VSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVL
EYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP
DRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
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| BDBM50032955 |
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| n/a |
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| Name | BDBM50032955 |
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| Synonyms: | 1,2,3,6-Tetrahydro-pyridine-4-carboxylic acid | 1,2,3,6-tetrahydropyridine-4-carboxylic acid | 1,2,3,6-tetrahydropyridinium-4-carboxylate | CHEMBL39071 | Isoguvacine |
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| Type | Small organic molecule |
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| Emp. Form. | C6H9NO2 |
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| Mol. Mass. | 127.1412 |
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| SMILES | OC(=O)C1=CCNCC1 |t:3| |
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| Structure | 
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