| Reaction Details |
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 | Report a problem with these data |
| Target | Microtubule-associated protein tau |
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| Ligand | BDBM50055949 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1459450 (CHEMBL3368556) |
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| IC50 | >10000±n/a nM |
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| Citation |  Fuse, S; Matsumura, K; Fujita, Y; Sugimoto, H; Takahashi, T Development of dual targeting inhibitors against aggregations of amyloid-ß and tau protein. Eur J Med Chem85:228-34 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Microtubule-associated protein tau |
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| Name: | Microtubule-associated protein tau |
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| Synonyms: | MAPT | MAPTL | MTBT1 | Microtubule-associated protein tau | Neurofibrillary tangle protein | PHF-tau | Paired helical filament-tau | TAU | TAU_HUMAN | Tau Protein |
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| Type: | Protein |
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| Mol. Mass.: | 78928.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10636 |
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| Residue: | 758 |
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| Sequence: | MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPG
SETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAG
HVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEG
GRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPA
QDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLE
FTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPA
AAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSS
DPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQK
GQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREP
KKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLD
LSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEK
LDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDT
SPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
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| BDBM50055949 |
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| n/a |
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| Name | BDBM50055949 |
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| Synonyms: | CHEMBL3330745 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H21N5OS2 |
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| Mol. Mass. | 555.672 |
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| SMILES | NC(=O)C(=C\c1ccc(s1)-c1ccc(-c2ccc(cc2)N(c2ccccc2)c2ccccc2)c2nsnc12)\C#N |
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| Structure | 
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