| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
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| Ligand | BDBM50063513 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1463265 (CHEMBL3399454) |
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| IC50 | 158489±n/a nM |
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| Citation |  Steffan, T; Renukappa-Gutke, T; Höfner, G; Wanner, KT Design, synthesis and SAR studies of GABA uptake inhibitors derived from 2-substituted pyrrolidine-2-yl-acetic acids. Bioorg Med Chem23:1284-306 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent noradrenaline transporter |
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| Name: | Sodium-dependent noradrenaline transporter |
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| Synonyms: | Norepinephrine transporter | SC6A2_MOUSE | Slc6a2 | Sodium-dependent noradrenaline transporter |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 69260.85 |
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| Organism: | MOUSE |
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| Description: | Norepinephrine transporter 0 MOUSE::O55192 |
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| Residue: | 617 |
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| Sequence: | MLLARMNPQVQPELGGADPLPEQPLRPCKTADLLVVKERNGVQCLLASQDSDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHSW
NSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVLFFLMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTCVVTISTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYTYPPWANWVGWGIALSSMILVPAYVIYKFLSIRGSLWERVAYGITPENEHHL
VAQRDVRQFQLRHWLAI
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| BDBM50063513 |
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| n/a |
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| Name | BDBM50063513 |
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| Synonyms: | CHEMBL3398496 |
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| Type | Small organic molecule |
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| Emp. Form. | C8H13F3N2O4 |
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| Mol. Mass. | 258.195 |
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| SMILES | OC(=O)C(F)(F)F.[H][C@@]1(CCCN1)[C@@H](N)C(O)=O |r| |
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| Structure | 
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