Reaction Details |
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Target | Thyroid hormone receptor beta |
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Ligand | BDBM50063693 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1463692 (CHEMBL3399151) |
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Ki | 1.0±n/a nM |
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Citation | Burkholder, TP; Cunningham, BE; Clayton, JR; Lander, PA; Brown, ML; Doti, RA; Durst, GL; Montrose-Rafizadeh, C; King, C; Osborne, HE; Amos, RM; Zink, RW; Stramm, LE; Burris, TP; Cardona, G; Konkol, DL; Reidy, C; Christe, ME; Genin, MJ Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptorß agonists. Bioorg Med Chem Lett25:1377-80 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thyroid hormone receptor beta |
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Name: | Thyroid hormone receptor beta |
Synonyms: | ERBA2 | NR1A2 | Nuclear receptor subfamily 1 group A member 2 | THB_HUMAN | THR1 | THRB | c-erbA-2 | c-erbA-beta |
Type: | Receptor |
Mol. Mass.: | 52793.62 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant hThR was obtained from nuclear extracts from SF9 cells infected with baculovirus vectors encoding for ThRbeta 1. |
Residue: | 461 |
Sequence: | MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQ
TTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYR
CITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVL
DDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWK
QKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCED
QIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSL
SSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPK
LLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED
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BDBM50063693 |
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n/a |
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Name | BDBM50063693 |
Synonyms: | CHEMBL3397333 |
Type | Small organic molecule |
Emp. Form. | C20H21NO4 |
Mol. Mass. | 339.385 |
SMILES | CC(C)c1cc(Cn2ccc3cc(OCC(O)=O)ccc23)ccc1O |
Structure |
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