Reaction Details |
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Target | Aldo-keto reductase family 1 member B7 |
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Ligand | BDBM16452 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1475204 (CHEMBL3424959) |
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IC50 | 49±n/a nM |
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Citation | Stefek, M; Soltesova Prnova, M; Majekova, M; Rechlin, C; Heine, A; Klebe, G Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold. J Med Chem58:2649-57 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aldo-keto reductase family 1 member B7 |
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Name: | Aldo-keto reductase family 1 member B7 |
Synonyms: | ALD1_RAT | Akr1b14 | Akr1b7 | Aldehyde reductase | Aldo-keto reductase family 1 member B7 | Aldose reductase-like protein AKR1B14 | Aldose reductase-related protein 1 |
Type: | PROTEIN |
Mol. Mass.: | 36127.39 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_109605 |
Residue: | 316 |
Sequence: | MTTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQ
EKIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGK
EFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKP
VTNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAK
HKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACG
LFVTSDEEDFPFHEEY
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BDBM16452 |
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n/a |
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Name | BDBM16452 |
Synonyms: | (4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | 2-(4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-yl]methyl}-3,4-dihydrophthalazin-1-yl)acetic acid | Alond | CHEMBL10372 | Xedia | Zopolrestat |
Type | Small organic molecule |
Emp. Form. | C19H12F3N3O3S |
Mol. Mass. | 419.377 |
SMILES | OC(=O)Cc1nn(Cc2nc3cc(ccc3s2)C(F)(F)F)c(=O)c2ccccc12 |
Structure |
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