| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B7 |
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| Ligand | BDBM50080465 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1475204 (CHEMBL3424959) |
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| IC50 | 14130±n/a nM |
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| Citation |  Stefek, M; Soltesova Prnova, M; Majekova, M; Rechlin, C; Heine, A; Klebe, G Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold. J Med Chem58:2649-57 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aldo-keto reductase family 1 member B7 |
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| Name: | Aldo-keto reductase family 1 member B7 |
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| Synonyms: | ALD1_RAT | Akr1b14 | Akr1b7 | Aldehyde reductase | Aldo-keto reductase family 1 member B7 | Aldose reductase-like protein AKR1B14 | Aldose reductase-related protein 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 36127.39 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_109605 |
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| Residue: | 316 |
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| Sequence: | MTTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQ
EKIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGK
EFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKP
VTNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAK
HKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACG
LFVTSDEEDFPFHEEY
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| BDBM50080465 |
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| n/a |
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| Name | BDBM50080465 |
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| Synonyms: | CHEMBL3422329 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H14N4O2S |
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| Mol. Mass. | 302.352 |
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| SMILES | CC(C)Sc1nnc2c3ccccc3n(CC(O)=O)c2n1 |
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| Structure | 
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