Reaction Details |
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Target | Bcl-2-like protein 1 |
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Ligand | BDBM50086689 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1477329 (CHEMBL3429295) |
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Ki | 7800±n/a nM |
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Citation | Burke, JP; Bian, Z; Shaw, S; Zhao, B; Goodwin, CM; Belmar, J; Browning, CF; Vigil, D; Friberg, A; Camper, DV; Rossanese, OW; Lee, T; Olejniczak, ET; Fesik, SW Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design. J Med Chem58:3794-805 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Bcl-2-like protein 1 |
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Name: | Bcl-2-like protein 1 |
Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
Type: | Mitochondrion membrane; Single-pass membrane protein |
Mol. Mass.: | 26039.60 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 233 |
Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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BDBM50086689 |
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n/a |
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Name | BDBM50086689 |
Synonyms: | CHEMBL3426330 |
Type | Small organic molecule |
Emp. Form. | C23H24ClNO3 |
Mol. Mass. | 397.895 |
SMILES | Cc1cc(OCCCc2c(C(O)=O)n3CCCc4cccc2c34)cc(C)c1Cl |
Structure |
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