Reaction Details |
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Target | Potassium voltage-gated channel subfamily E/KQT member 1 |
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Ligand | BDBM50109647 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1478576 (CHEMBL3430477) |
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IC50 | 19953±n/a nM |
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Citation | Mirams, GR; Davies, MR; Brough, SJ; Bridgland-Taylor, MH; Cui, Y; Gavaghan, DJ; Abi-Gerges, N Prediction of Thorough QT study results using action potential simulations based on ion channel screens. J Pharmacol Toxicol Methods70:246-54 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Potassium voltage-gated channel subfamily E/KQT member 1 |
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Name: | Potassium voltage-gated channel subfamily E/KQT member 1 |
Synonyms: | Voltage-gated potassium channel beta subunit Mink/subunit Kv7.1 | Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 158552 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Potassium voltage-gated channel subfamily E member 1 |
Synonyms: | Delayed rectifier potassium channel subunit IsK | IKs producing slow voltage-gated potassium channel subunit beta Mink | KCNE1 | KCNE1_HUMAN | KCNQ1(Kv7.1)/KCNE1(MinK) | Minimal potassium channel | Voltage-gated potassium channel beta subunit Mink | Voltage-gated potassium channel, IKs |
Type: | PROTEIN |
Mol. Mass.: | 14676.11 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1456351 |
Residue: | 129 |
Sequence: | MILSNTTAVTPFLTKLWQETVQQGGNMSGLARRSPRSSDGKLEALYVLMVLGFFGFFTLG
IMLSYIRSKKLEHSNDPFNVYIESDAWQEKDKAYVQARVLESYRSCYVVENHLAIEQPNT
HLPETKPSP
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Component 2 |
Name: | Potassium voltage-gated channel subfamily KQT member 1 |
Synonyms: | KCNA8 | KCNA9 | KCNQ (Kv7) potassium channel | KCNQ1 | KCNQ1_HUMAN | KVLQT1 | Voltage-gated potassium channel subunit Kv7.1 | Voltage-gated potassium channel subunit Kv7.1/Misshapen-like kinase 1 |
Type: | PROTEIN |
Mol. Mass.: | 74739.00 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1454245 |
Residue: | 676 |
Sequence: | MAAASSPPRAERKRWGWGRLPGARRGSAGLAKKCPFSLELAEGGPAGGALYAPIAPGAPG
PAPPASPAAPAAPPVASDLGPRPPVSLDPRVSIYSTRRPVLARTHVQGRVYNFLERPTGW
KCFVYHFAVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGC
RSKYVGLWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLH
VDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRVEFGSYA
DALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQR
QKHFNRQIPAAASLIQTAWRCYAAENPDSSTWKIYIRKAPRSHTLLSPSPKPKKSVVVKK
KKFKLDKDNGVTPGEKMLTVPHITCDPPEERRLDHFSVDGYDSSVRKSPTLLEVSMPHFM
RTNSFAEDLDLEGETLLTPITHISQLREHHRATIKVIRRMQYFVAKKKFQQARKPYDVRD
VIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFISVSEKSKDRGSNTIGARLNRVEDKVT
QLDQRLALITDMLHQLLSLHGGSTPGSGGPPREGGAHITQPCGSGGSVDPELFLPSNTLP
TYEQLTVPRRGPDEGS
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BDBM50109647 |
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n/a |
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Name | BDBM50109647 |
Synonyms: | 2-{1-[2-(2,3-Dihydro-benzofuran-5-yl)-ethyl]-pyrrolidin-3-yl}-2,2-diphenyl-acetamide (Darifenacin) | CHEMBL1346 | DARIFENACIN | DARIFENACIN HYDROBROMIDE | Enablex |
Type | Small organic molecule |
Emp. Form. | C28H30N2O2 |
Mol. Mass. | 426.55 |
SMILES | NC(=O)C([C@@H]1CCN(CCc2ccc3OCCc3c2)C1)(c1ccccc1)c1ccccc1 |
Structure |
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