Reaction Details |
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Target | Nuclear receptor ROR-gamma |
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Ligand | BDBM50108882 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1506713 (CHEMBL3598804) |
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IC50 | 300±n/a nM |
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Citation | Chao, J; Enyedy, I; Van Vloten, K; Marcotte, D; Guertin, K; Hutchings, R; Powell, N; Jones, H; Bohnert, T; Peng, CC; Silvian, L; Hong, VS; Little, K; Banerjee, D; Peng, L; Taveras, A; Viney, JL; Fontenot, J Discovery of biaryl carboxylamides as potent ROR¿ inverse agonists. Bioorg Med Chem Lett25:2991-7 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Nuclear receptor ROR-gamma |
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Name: | Nuclear receptor ROR-gamma |
Synonyms: | NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 58218.40 |
Organism: | Homo sapiens (Human) |
Description: | P51449 |
Residue: | 518 |
Sequence: | MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQR
CNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQK
QLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKAS
GSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPG
LGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIF
SREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEV
VLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALY
TALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV
ERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
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BDBM50108882 |
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n/a |
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Name | BDBM50108882 |
Synonyms: | CHEMBL3596593 |
Type | Small organic molecule |
Emp. Form. | C24H20ClFN2O2 |
Mol. Mass. | 422.879 |
SMILES | Cc1ccc(cc1-c1ccc2N(CCCc2c1)C(=O)c1c(F)cccc1Cl)C(N)=O |
Structure |
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