| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50112266 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1513072 (CHEMBL3610409) |
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| IC50 | 36000±n/a nM |
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| Citation |  Cox, BD; Prosser, AR; Sun, Y; Li, Z; Lee, S; Huang, MB; Bond, VC; Snyder, JP; Krystal, M; Wilson, LJ; Liotta, DC Pyrazolo-Piperidines Exhibit Dual Inhibition of CCR5/CXCR4 HIV Entry and Reverse Transcriptase. ACS Med Chem Lett6:753-7 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40540.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51681 |
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| Residue: | 352 |
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| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| BDBM50112266 |
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| n/a |
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| Name | BDBM50112266 |
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| Synonyms: | CHEMBL3608763 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24N4 |
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| Mol. Mass. | 332.4421 |
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| SMILES | C(N1CCC(CC1)c1[nH]ncc1Cc1ccccc1)c1ccncc1 |
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| Structure | 
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