| Reaction Details |
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 | Report a problem with these data |
| Target | Transient receptor potential cation channel subfamily V member 4 |
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| Ligand | BDBM50117650 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1514407 (CHEMBL3615486) |
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| IC50 | 800±n/a nM |
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| Citation |  Wei, ZL; Nguyen, MT; O'Mahony, DJ; Acevedo, A; Zipfel, S; Zhang, Q; Liu, L; Dourado, M; Chi, C; Yip, V; DeFalco, J; Gustafson, A; Emerling, DE; Kelly, MG; Kincaid, J; Vincent, F; Duncton, MA Identification of orally-bioavailable antagonists of the TRPV4 ion-channel. Bioorg Med Chem Lett25:4011-5 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Transient receptor potential cation channel subfamily V member 4 |
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| Name: | Transient receptor potential cation channel subfamily V member 4 |
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| Synonyms: | TRPV4 | TRPV4_HUMAN | Transient receptor potential cation channel subfamily V member 4 (TRPV4) | VRL2 | VROAC |
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| Type: | Enzyme |
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| Mol. Mass.: | 98290.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9HBA0 |
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| Residue: | 871 |
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| Sequence: | MADSSEGPRAGPGEVAELPGDESGTPGGEAFPLSSLANLFEGEDGSLSPSPADASRPAGP
GDGRPNLRMKFQGAFRKGVPNPIDLLESTLYESSVVPGPKKAPMDSLFDYGTYRHHSSDN
KRWRKKIIEKQPQSPKAPAPQPPPILKVFNRPILFDIVSRGSTADLDGLLPFLLTHKKRL
TDEEFREPSTGKTCLPKALLNLSNGRNDTIPVLLDIAERTGNMREFINSPFRDIYYRGQT
ALHIAIERRCKHYVELLVAQGADVHAQARGRFFQPKDEGGYFYFGELPLSLAACTNQPHI
VNYLTENPHKKADMRRQDSRGNTVLHALVAIADNTRENTKFVTKMYDLLLLKCARLFPDS
NLEAVLNNDGLSPLMMAAKTGKIGIFQHIIRREVTDEDTRHLSRKFKDWAYGPVYSSLYD
LSSLDTCGEEASVLEILVYNSKIENRHEMLAVEPINELLRDKWRKFGAVSFYINVVSYLC
AMVIFTLTAYYQPLEGTPPYPYRTTVDYLRLAGEVITLFTGVLFFFTNIKDLFMKKCPGV
NSLFIDGSFQLLYFIYSVLVIVSAALYLAGIEAYLAVMVFALVLGWMNALYFTRGLKLTG
TYSIMIQKILFKDLFRFLLVYLLFMIGYASALVSLLNPCANMKVCNEDQTNCTVPTYPSC
RDSETFSTFLLDLFKLTIGMGDLEMLSSTKYPVVFIILLVTYIILTFVLLLNMLIALMGE
TVGQVSKESKHIWKLQWATTILDIERSFPVFLRKAFRSGEMVTVGKSSDGTPDRRWCFRV
DEVNWSHWNQNLGIINEDPGKNETYQYYGFSHTVGRLRRDRWSSVVPRVVELNKNSNPDE
VVVPLDSMGNPRCDGHQQGYPRKWRTDDAPL
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| BDBM50117650 |
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| n/a |
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| Name | BDBM50117650 |
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| Synonyms: | CHEMBL3613638 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26F3N3O3S |
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| Mol. Mass. | 481.531 |
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| SMILES | FC(F)(F)c1ccc(cc1)C(=O)Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)C1CCCC1 |
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| Structure | 
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