| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Ligand | BDBM50117841 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1515874 (CHEMBL3614737) |
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| IC50 | 2100±n/a nM |
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| Citation |  Li, YL; Qi, XY; Jiang, H; Deng, XD; Dong, YP; Ding, TB; Zhou, L; Men, P; Chu, Y; Wang, RX; Jiang, XC; Ye, DY Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors. Bioorg Med Chem23:6173-84 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Name: | Phosphatidylcholine:ceramide cholinephosphotransferase 1 |
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| Synonyms: | MOB | Medulla oblongata-derived protein | Protein Mob | SGMS1 | SMS1 | SMS1_HUMAN | Sphingomyelin synthase 1 | TMEM23 | Transmembrane protein 23 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48630.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109868 |
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| Residue: | 413 |
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| Sequence: | MKEVVYWSPKKVADWLLENAMPEYCEPLEHFTGQDLINLTQEDFKKPPLCRVSSDNGQRL
LDMIETLKMEHHLEAHKNGHANGHLNIGVDIPTPDGSFSIKIKPNGMPNGYRKEMIKIPM
PELERSQYPMEWGKTFLAFLYALSCFVLTTVMISVVHERVPPKEVQPPLPDTFFDHFNRV
QWAFSICEINGMILVGLWLIQWLLLKYKSIISRRFFCIVGTLYLYRCITMYVTTLPVPGM
HFNCSPKLFGDWEAQLRRIMKLIAGGGLSITGSHNMCGDYLYSGHTVMLTLTYLFIKEYS
PRRLWWYHWICWLLSVVGIFCILLAHDHYTVDVVVAYYITTRLFWWYHTMANQQVLKEAS
QMNLLARVWWYRPFQYFEKNVQGIVPRSYHWPFPWPVVHLSRQVKYSRLVNDT
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| BDBM50117841 |
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| n/a |
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| Name | BDBM50117841 |
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| Synonyms: | CHEMBL3613983 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23BrN2O4S |
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| Mol. Mass. | 503.409 |
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| SMILES | Brc1ccc(CNC(=O)COc2ccc(cc2)S(=O)(=O)NCCc2ccccc2)cc1 |
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| Structure | 
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