Reaction Details |
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Target | Tyrosine-protein kinase HCK |
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Ligand | BDBM50119568 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1517136 (CHEMBL3619919) |
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Ki | 730±n/a nM |
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Citation | Kwarcinski, FE; Steffey, ME; Fox, CC; Soellner, MB Discovery of Bivalent Kinase Inhibitors via Enzyme-Templated Fragment Elaboration. ACS Med Chem Lett6:898-901 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase HCK |
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Name: | Tyrosine-protein kinase HCK |
Synonyms: | HCK | HCK_HUMAN | Hematopoietic cell kinase | Hemopoietic cell kinase | p59-HCK/p60-HCK | p59Hck | p61Hck |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 59600.18 |
Organism: | Homo sapiens (Human) |
Description: | P08631 |
Residue: | 526 |
Sequence: | MGGRSSCEDPGCPRDEERAPRMGCMKSKFLQVGGNTFSKTETSASPHCPVYVPDPTSTIK
PGPNSHNSNTPGIREAGSEDIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSL
ATRKEGYIPSNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGSY
SLSVRDYDPRQGDTVKHYKIRTLDNGGFYISPRSTFSTLQELVDHYKKGNDGLCQKLSVP
CMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVE
AFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEFMAKGSLLDFLKSDEGSKQPLPKLID
FSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIEDNEYTAREGAKFP
IKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPE
NCPEELYNIMMRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
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BDBM50119568 |
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n/a |
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Name | BDBM50119568 |
Synonyms: | CHEMBL3617738 |
Type | Small organic molecule |
Emp. Form. | C31H36N8O3 |
Mol. Mass. | 568.6693 |
SMILES | O=C(CCCCCC(=O)N1CCC[C@@H]1c1ccco1)Nc1cccc(Nc2nccc(Nc3cc([nH]n3)C3CC3)n2)c1 |r| |
Structure |
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