Reaction Details |
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Target | DNA topoisomerase 1 |
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Ligand | BDBM50013078 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1520827 (CHEMBL3626095) |
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EC50 | 48950±n/a nM |
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Citation | Majumdar, P; Bathula, C; Basu, SM; Das, SK; Agarwal, R; Hati, S; Singh, A; Sen, S; Das, BB Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity. Eur J Med Chem102:540-51 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA topoisomerase 1 |
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Name: | DNA topoisomerase 1 |
Synonyms: | DNA topoisomerase I | DNA topoisomerase I (Topo I) | TOP1 | TOP1_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 90771.02 |
Organism: | Homo sapiens (Human) |
Description: | P11387 |
Residue: | 765 |
Sequence: | MSGDHLHNDSQIEADFRLNDSHKHKDKHKDREHRHKEHKKEKDREKSKHSNSEHKDSEKK
HKEKEKTKHKDGSSEKHKDKHKDRDKEKRKEEKVRASGDAKIKKEKENGFSSPPQIKDEP
EDDGYFVPPKEDIKPLKRPRDEDDADYKPKKIKTEDTKKEKKRKLEEEEDGKLKKPKNKD
KDKKVPEPDNKKKKPKKEEEQKWKWWEEERYPEGIKWKFLEHKGPVFAPPYEPLPENVKF
YYDGKVMKLSPKAEEVATFFAKMLDHEYTTKEIFRKNFFKDWRKEMTNEEKNIITNLSKC
DFTQMSQYFKAQTEARKQMSKEEKLKIKEENEKLLKEYGFCIMDNHKERIANFKIEPPGL
FRGRGNHPKMGMLKRRIMPEDIIINCSKDAKVPSPPPGHKWKEVRHDNKVTWLVSWTENI
QGSIKYIMLNPSSRIKGEKDWQKYETARRLKKCVDKIRNQYREDWKSKEMKVRQRAVALY
FIDKLALRAGNEKEEGETADTVGCCSLRVEHINLHPELDGQEYVVEFDFLGKDSIRYYNK
VPVEKRVFKNLQLFMENKQPEDDLFDRLNTGILNKHLQDLMEGLTAKVFRTYNASITLQQ
QLKELTAPDENIPAKILSYNRANRAVAILCNHQRAPPKTFEKSMMNLQTKIDAKKEQLAD
ARRDLKSAKADAKVMKDAKTKKVVESKKKAVQRLEEQLMKLEVQATDREENKQIALGTSK
LNYLDPRITVAWCKKWGVPIEKIYNKTQREKFAWAIDMADEDYEF
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BDBM50013078 |
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n/a |
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Name | BDBM50013078 |
Synonyms: | CHEMBL3623261 |
Type | Small organic molecule |
Emp. Form. | C13H11N3OS |
Mol. Mass. | 257.311 |
SMILES | Cn1cc(\C=C2\NC(=S)NC2=O)c2ccccc12 |
Structure |
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