| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polyphenol oxidase 2 |
|---|
| Ligand | BDBM50133898 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1526710 (CHEMBL3636248) |
|---|
| Ki | 10300±n/a nM |
|---|
| Citation |  Radhakrishnan, S; Shimmon, R; Conn, C; Baker, A Inhibitory kinetics of novel 2,3-dihydro-1H-inden-1-one chalcone-like derivatives on mushroom tyrosinase. Bioorg Med Chem Lett25:5495-9 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polyphenol oxidase 2 |
|---|
| Name: | Polyphenol oxidase 2 |
|---|
| Synonyms: | Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 63923.66 |
|---|
| Organism: | Agaricus bisporus (Common mushroom) |
|---|
| Description: | O42713 |
|---|
| Residue: | 556 |
|---|
| Sequence: | MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLP
FTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWV
QAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPY
GDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDD
QHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVW
VTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGG
TKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKK
FELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNH
YLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDH
TQARVVFDDVAVHVIN
|
|
|
|---|
| BDBM50133898 |
|---|
| n/a |
|---|
| Name | BDBM50133898 |
|---|
| Synonyms: | CHEMBL3634266 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H12O3 |
|---|
| Mol. Mass. | 252.2647 |
|---|
| SMILES | Oc1ccc(\C=C2\Cc3ccccc3C2=O)c(O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
