Reaction Details |
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Target | Tryptophan 5-hydroxylase 1 |
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Ligand | BDBM50145647 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1556269 (CHEMBL3769268) |
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IC50 | 871±n/a nM |
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Citation | Goldberg, DR; De Lombaert, S; Aiello, R; Bourassa, P; Barucci, N; Zhang, Q; Paralkar, V; Valentine, J; Zavadoski, W Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett26:1124-9 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tryptophan 5-hydroxylase 1 |
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Name: | Tryptophan 5-hydroxylase 1 |
Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
Type: | PROTEIN |
Mol. Mass.: | 50990.64 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1361824 |
Residue: | 444 |
Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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BDBM50145647 |
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n/a |
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Name | BDBM50145647 |
Synonyms: | CHEMBL3764524 |
Type | Small organic molecule |
Emp. Form. | C26H29ClF3N7O3 |
Mol. Mass. | 580.002 |
SMILES | CN1CC2(C[C@H]1C(O)=O)CCN(CC2)c1cc(O[C@H](c2ccc(Cl)cc2-n2ccc(C)n2)C(F)(F)F)nc(N)n1 |r| |
Structure |
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