| Reaction Details |
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 | Report a problem with these data |
| Target | Tryptophan 5-hydroxylase 1 |
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| Ligand | BDBM50145653 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1556269 (CHEMBL3769268) |
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| IC50 | 2961±n/a nM |
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| Citation |  Goldberg, DR; De Lombaert, S; Aiello, R; Bourassa, P; Barucci, N; Zhang, Q; Paralkar, V; Valentine, J; Zavadoski, W Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett26:1124-9 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tryptophan 5-hydroxylase 1 |
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| Name: | Tryptophan 5-hydroxylase 1 |
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| Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 50990.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1361824 |
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| Residue: | 444 |
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| Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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| BDBM50145653 |
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| n/a |
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| Name | BDBM50145653 |
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| Synonyms: | CHEMBL3764091 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27ClF3N7O3 |
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| Mol. Mass. | 565.975 |
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| SMILES | Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(N)nc(n1)N1CCC2(CNC(C2)C(O)=O)CC1)C(F)(F)F |r| |
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| Structure | 
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