Reaction Details |
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Target | Tryptophan 5-hydroxylase 1 |
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Ligand | BDBM50145662 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1556269 (CHEMBL3769268) |
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IC50 | 2714±n/a nM |
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Citation | Goldberg, DR; De Lombaert, S; Aiello, R; Bourassa, P; Barucci, N; Zhang, Q; Paralkar, V; Valentine, J; Zavadoski, W Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett26:1124-9 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tryptophan 5-hydroxylase 1 |
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Name: | Tryptophan 5-hydroxylase 1 |
Synonyms: | TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1 |
Type: | PROTEIN |
Mol. Mass.: | 50990.64 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1361824 |
Residue: | 444 |
Sequence: | MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEF
EIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCAN
RVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQE
LNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRD
FLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGA
SEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITC
KQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSA
MNELQHDLDVVSDALAKVSRKPSI
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BDBM50145662 |
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n/a |
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Name | BDBM50145662 |
Synonyms: | CHEMBL3765662 |
Type | Small organic molecule |
Emp. Form. | C24H26ClF3N6O3 |
Mol. Mass. | 538.95 |
SMILES | Cc1ccn(n1)-c1cc(Cl)ccc1[C@@H](Oc1cc(nc(N)n1)N1CCC(CCC(O)=O)CC1)C(F)(F)F |r| |
Structure |
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