| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor XII |
|---|
| Ligand | BDBM50146946 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1553874 (CHEMBL3767388) |
|---|
| IC50 | 41000±n/a nM |
|---|
| Citation |  Bouckaert, C; Serra, S; Rondelet, G; Dolu?ic, E; Wouters, J; Dogné, JM; Frédérick, R; Pochet, L Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors. Eur J Med Chem110:181-94 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor XII |
|---|
| Name: | Coagulation factor XII |
|---|
| Synonyms: | Beta-factor XIIa part 1 | Beta-factor XIIa part 2 | Carboxylesterase 2 (intestine, liver) | Coagulation factor XII | Coagulation factor XII (FXII) | Coagulation factor XIIa heavy chain | Coagulation factor XIIa light chain | F12 | FA12_HUMAN | Factor XIIa | Factor XIIa (fXIIa) | HAF | Hageman factor |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 67810.07 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00748 |
|---|
| Residue: | 615 |
|---|
| Sequence: | MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK
CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL
CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT
NPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP
WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ
AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG
QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP
EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP
YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS
SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT
DVAYYLAWIREHTVS
|
|
|
|---|
| BDBM50146946 |
|---|
| n/a |
|---|
| Name | BDBM50146946 |
|---|
| Synonyms: | CHEMBL3763449 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H9BrClNO4 |
|---|
| Mol. Mass. | 394.604 |
|---|
| SMILES | Oc1ccc(NC(=O)c2cc3cc(Cl)cc(Br)c3oc2=O)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
