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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM50152605 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1564733 (CHEMBL3784138) | ||
| IC50 | 6.0±n/a nM | ||
| Citation |  Simov, V; Deshmukh, SV; Dinsmore, CJ; Elwood, F; Fernandez, RB; Garcia, Y; Gibeau, C; Gunaydin, H; Jung, J; Katz, JD; Kraybill, B; Lapointe, B; Patel, SB; Siu, T; Su, H; Young, JR Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors. Bioorg Med Chem Lett26:1803-8 (2016) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
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| BDBM50152605 | |||
| n/a | |||
| Name | BDBM50152605 | ||
| Synonyms: | CHEMBL3780977 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H25N5O | ||
| Mol. Mass. | 363.4561 | ||
| SMILES | Cc1[nH]c(nc1-c1ccccc1)-c1c(N[C@@H]2CC[C@H](N)CC2)cc[nH]c1=O |r,wU:15.16,18.20,(1.49,6.43,;.77,5.43,;1.24,3.97,;,3.08,;-1.25,3.96,;-.77,5.43,;-1.68,6.67,;-1.17,8.12,;-2.16,9.29,;-3.68,9.01,;-4.2,7.56,;-3.2,6.39,;,1.54,;-1.33,.77,;-2.67,1.54,;-4,.77,;-5.34,1.53,;-6.67,.76,;-6.67,-.78,;-7.73,-1.4,;-5.33,-1.55,;-4,-.77,;-1.33,-.77,;,-1.54,;1.33,-.77,;1.33,.77,;2.4,1.39,)| | ||
| Structure | 
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