| Reaction Details |
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 | Report a problem with these data |
| Target | Synaptic vesicular amine transporter |
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| Ligand | BDBM50161097 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1571954 (CHEMBL3796412) |
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| Ki | 63±n/a nM |
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| Citation |  Joolakanti, SR; Nickell, JR; Janganati, V; Zheng, G; Dwoskin, LP; Crooks, PA Lobelane analogues containing 4-hydroxy and 4-(2-fluoroethoxy) aromatic substituents: Potent and selective inhibitors of [(3)H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg Med Chem Lett26:2422-7 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Synaptic vesicular amine transporter |
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| Name: | Synaptic vesicular amine transporter |
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| Synonyms: | Monoamine transporter | Slc18a2 | Solute carrier family 18 member 2 | Svat | Synaptic vesicular amine transporter | VAT2 | VMAT2_RAT | Vesicular amine transporter 2 | Vesicular monoamine transporter 2 (VMAT2) | Vmat2 |
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| Type: | Protein |
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| Mol. Mass.: | 55689.58 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | Q01827 |
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| Residue: | 515 |
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| Sequence: | MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEI
QTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPS
EDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFS
SSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFG
SVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAG
SICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWL
CALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYG
SVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEK
MAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
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| BDBM50161097 |
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| n/a |
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| Name | BDBM50161097 |
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| Synonyms: | CHEMBL3793787 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H37ClFNO4 |
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| Mol. Mass. | 482.028 |
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| SMILES | Cl.OC[C@H](O)CN1[C@@H](CCc2ccc(O)cc2)CCC[C@H]1CCc1ccc(OCCF)cc1 |r| |
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| Structure | 
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