Reaction Details |
| Report a problem with these data |
Target | Carbonic anhydrase 9 |
---|
Ligand | BDBM50334354 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_1579081 (CHEMBL3811429) |
---|
Ki | 45±n/a nM |
---|
Citation | Abdel Gawad, NM; Amin, NH; Elsaadi, MT; Mohamed, FMM; Angeli, A; De Luca, V; Capasso, C; Supuran, CT Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines. Bioorg Med Chem24:3043-3051 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Carbonic anhydrase 9 |
---|
Name: | Carbonic anhydrase 9 |
Synonyms: | CA-IX | CA9 | CAH9_HUMAN | Carbonate dehydratase IX | Carbonic anhydrase 9 (CA IX) | Carbonic anhydrase 9 (CAIX) | Carbonic anhydrase 9 precursor | Carbonic anhydrase IX (CA IX) | Carbonic anhydrase IX (CAIX) | Carbonic anhydrases IX | Carbonic anhydrases; II & IX | G250 | MN | Membrane antigen MN | RCC-associated antigen G250 |
Type: | Enzyme |
Mol. Mass.: | 49669.03 |
Organism: | Homo sapiens (Human) |
Description: | Catalytic domain of human cloned isozyme was used in the assay |
Residue: | 459 |
Sequence: | MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPL
GEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPG
DPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPL
ELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHT
VEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIA
EEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLS
DTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVF
GLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
|
|
|
BDBM50334354 |
---|
n/a |
---|
Name | BDBM50334354 |
Synonyms: | 4-(3-(4-fluorophenyl)ureido)benzenesulfonamide | 4-{[(4'-Fluorophenyl)carbamoyl]amino}benzenesulfonamide | 4-{[(4-fluorophenyl)carbamoyl]amino}benzenesulfonamide | CHEMBL1615281 |
Type | Small organic molecule |
Emp. Form. | C13H12FN3O3S |
Mol. Mass. | 309.316 |
SMILES | NS(=O)(=O)c1ccc(NC(=O)Nc2ccc(F)cc2)cc1 |
Structure |
|