| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sphingosine kinase 2 |
|---|
| Ligand | BDBM50178357 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1583243 (CHEMBL3816961) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Xi, M; Ge, J; Wang, X; Sun, C; Liu, T; Fang, L; Xiao, Q; Yin, D Development of hydroxy-based sphingosine kinase inhibitors and anti-inflammation in dextran sodium sulfate induced colitis in mice. Bioorg Med Chem24:3218-30 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sphingosine kinase 2 |
|---|
| Name: | Sphingosine kinase 2 |
|---|
| Synonyms: | SK 2 | SK2 | SPHK2 | SPHK2_HUMAN | SPK 2 | Sphingosine kinase 2 | Sphingosine kinase types 2 (SphK2) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 69221.44 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q9NRA0 |
|---|
| Residue: | 654 |
|---|
| Sequence: | MNGHLEAEEQQDQRPDQELTGSWGHGPRSTLVRAKAMAPPPPPLAASTPLLHGEFGSYPA
RGPRFALTLTSQALHIQRLRPKPEARPRGGLVPLAEVSGCCTLRSRSPSDSAAYFCIYTY
PRGRRGARRRATRTFRADGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRP
PRLLLLVNPFGGRGLAWQWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDG
IVTVSGDGLLHEVLNGLLDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDL
LLNCSLLLCRGGGHPLDLLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTL
GTVLGLATLHTYRGRLSYLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSV
SDLPLPLPQPALASPGSPEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKA
ALHSPVSEGAPVIPPSSGLPLPTPDARVGASTCGPPDHLLPPLGTPLPPDWVTLEGDFVL
MLAISPSHLGADLVAAPHARFDDGLVHLCWVRSGISRAALLRLFLAMERGSHFSLGCPQL
GYAAARAFRLEPLTPRGVLTVDGEQVEYGPLQAQMHPGIGTLLTGPPGCPGREP
|
|
|
|---|
| BDBM50178357 |
|---|
| n/a |
|---|
| Name | BDBM50178357 |
|---|
| Synonyms: | CHEMBL3814603 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H17F3N2O3 |
|---|
| Mol. Mass. | 414.3772 |
|---|
| SMILES | Oc1cccc(c1)C(=O)N\N=C\c1cccc(OCc2ccccc2C(F)(F)F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
