Reaction Details |
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Target | Heat shock cognate 71 kDa protein |
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Ligand | BDBM50184987 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1588265 (CHEMBL3825930) |
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Kd | >1000000±n/a nM |
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Citation | Cheeseman, MD; Westwood, IM; Barbeau, O; Rowlands, M; Dobson, S; Jones, AM; Jeganathan, F; Burke, R; Kadi, N; Workman, P; Collins, I; van Montfort, RL; Jones, K Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70. J Med Chem59:4625-36 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heat shock cognate 71 kDa protein |
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Name: | Heat shock cognate 71 kDa protein |
Synonyms: | HSC70 | HSP73 | HSP7C_HUMAN | HSPA10 | HSPA8 | heat shock 70kDa protein 8 isoform 1 | heat shock 70kDa protein 8 isoform 2 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 70887.67 |
Organism: | Homo sapiens (Human) |
Description: | gi_5729877 |
Residue: | 646 |
Sequence: | MSKGPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVA
MNPTNTVFDAKRLIGRRFDDAVVQSDMKHWPFMVVNDAGRPKVQVEYKGETKSFYPEEVS
SMVLTKMKEIAEAYLGKTVTNAVVTVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAA
IAYGLDKKVGAERNVLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVNH
FIAEFKRKHKKDISENKRAVRRLRTACERAKRTLSSSTQASIEIDSLYEGIDFYTSITRA
RFEELNADLFRGTLDPVEKALRDAKLDKSQIHDIVLVGGSTRIPKIQKLLQDFFNGKELN
KSINPDEAVAYGAAVQAAILSGDKSENVQDLLLLDVTPLSLGIETAGGVMTVLIKRNTTI
PTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNNLLGKFELTGIPPAPRGVPQIEVTFDI
DANGILNVSAVDKSTGKENKITITNDKGRLSKEDIERMVQEAEKYKAEDEKQRDKVSSKN
SLESYAFNMKATVEDEKLQGKINDEDKQKILDKCNEIINWLDKNQTAEKEEFEHQQKELE
KVCNPIITKLYQSAGGMPGGMPGGFPGGGAPPSGGASSGPTIEEVD
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BDBM50184987 |
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n/a |
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Name | BDBM50184987 |
Synonyms: | CHEMBL3822515 |
Type | Small organic molecule |
Emp. Form. | C11H15N5O5 |
Mol. Mass. | 297.2673 |
SMILES | COc1nc2c(N)ncnc2n1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O |r| |
Structure |
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