| Reaction Details |
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 | Report a problem with these data |
| Target | Membrane primary amine oxidase |
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| Ligand | BDBM50205332 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1628173 (CHEMBL3870758) |
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| IC50 | 460±n/a nM |
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| Citation |  Yamaki, S; Suzuki, D; Fujiyasu, J; Neya, M; Nagashima, A; Kondo, M; Akabane, T; Kadono, K; Moritomo, A; Yoshihara, K Synthesis and structure activity relationships of glycine amide derivatives as novel Vascular Adhesion Protein-1 inhibitors. Bioorg Med Chem25:187-201 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Membrane primary amine oxidase |
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| Name: | Membrane primary amine oxidase |
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| Synonyms: | AOC3 | AOC3_HUMAN | Amine oxidase, copper containing | Semicarbazide-sensitive amine oxidase (SSAO) | Semicarbazide-sensitive amine oxidase/ Vascular adhesion protein 1 (SSAO/VAP-1) | VAP1 | Vascular adhesion protein 1 (VAP-1) |
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| Type: | Protein |
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| Mol. Mass.: | 84620.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16853 |
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| Residue: | 763 |
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| Sequence: | MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLF
ADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPP
AREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDID
QMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFL
HHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSW
SLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLV
YEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQ
APKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFH
PSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVW
AEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHP
RGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDF
SDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSA
DSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN
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| BDBM50205332 |
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| n/a |
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| Name | BDBM50205332 |
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| Synonyms: | CHEMBL3913195 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22ClN3O2 |
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| Mol. Mass. | 347.839 |
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| SMILES | Cl.CN(Cc1cccc(c1)-c1ccc(NC(C)=O)cc1)C(=O)CN |
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| Structure | 
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