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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Carbonic anhydrase 7 | ||
| Ligand | BDBM50211512 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1636650 (CHEMBL3879548) | ||
| Ki | 89±n/a nM | ||
| Citation |  Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties. Bioorg Med Chem25:1456-1464 (2017) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Carbonic anhydrase 7 | |||
| Name: | Carbonic anhydrase 7 | ||
| Synonyms: | CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 29664.11 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Human cloned isozyme. | ||
| Residue: | 264 | ||
| Sequence: |
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| BDBM50211512 | |||
| n/a | |||
| Name | BDBM50211512 | ||
| Synonyms: | CHEMBL3982616 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H15Cl2N5O7S | ||
| Mol. Mass. | 576.366 | ||
| SMILES | NS(=O)(=O)c1ccc(NC(=O)c2c(NC(=O)c3ccc(cc3)[N+]([O-])=O)onc2-c2c(Cl)cccc2Cl)cc1 |(15.83,-4.82,;14.49,-5.59,;12.94,-5.59,;13.71,-4.25,;14.49,-7.13,;15.82,-7.9,;15.83,-9.43,;14.5,-10.21,;14.5,-11.74,;15.83,-12.5,;17.16,-11.73,;15.84,-14.04,;14.6,-14.94,;13.14,-14.47,;11.99,-15.52,;12.32,-17.03,;10.52,-15.05,;10.19,-13.54,;8.72,-13.07,;7.57,-14.11,;7.91,-15.63,;9.39,-16.09,;6.09,-13.65,;5.76,-12.13,;4.95,-14.69,;15.08,-16.4,;16.62,-16.39,;17.08,-14.93,;18.62,-14.92,;19.38,-13.59,;18.6,-12.26,;20.92,-13.58,;21.7,-14.92,;20.94,-16.26,;19.39,-16.26,;18.62,-17.6,;13.17,-9.43,;13.17,-7.9,)| | ||
| Structure | 
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