Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50081905 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_53943 (CHEMBL668662) |
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Ki | 331±n/a nM |
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Citation | Li, RL; Dietrich, SW; Hansch, C Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted-benzyl)-2,4-diaminopyrimidines. J Med Chem24:538-44 (1981) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR) |
Type: | Enzyme |
Mol. Mass.: | 21603.71 |
Organism: | Bos taurus (Cattle) |
Description: | P00376 |
Residue: | 187 |
Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSS
VYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKF
EVYEKNN
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BDBM50081905 |
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n/a |
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Name | BDBM50081905 |
Synonyms: | 5-(3-Butoxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL31946 |
Type | Small organic molecule |
Emp. Form. | C15H20N4O |
Mol. Mass. | 272.3455 |
SMILES | CCCCOc1cccc(Cc2cnc(N)nc2N)c1 |
Structure |
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