| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50081909 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_54733 (CHEMBL668773) |
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| Ki | 102±n/a nM |
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| Citation |  Li, RL; Dietrich, SW; Hansch, C Quantitative structure-selectivity relationships. Comparison of the inhibition of Escherichia coli and bovine liver dihydrofolate reductase by 5-(substituted-benzyl)-2,4-diaminopyrimidines. J Med Chem24:538-44 (1981) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | Dihydrofolate reductase (F31V) | dfrA17 |
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| Type: | n/a |
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| Mol. Mass.: | 17532.46 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 157 |
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| Sequence: | MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYA
VVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHV
EVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG
|
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|
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| BDBM50081909 |
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| n/a |
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| Name | BDBM50081909 |
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| Synonyms: | 5-(3-(benzyloxy)benzyl)pyrimidine-2,4-diamine | 5-(3-Benzyloxy-benzyl)-pyrimidine-2,4-diamine | CHEMBL274031 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18N4O |
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| Mol. Mass. | 306.3617 |
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| SMILES | Nc1ncc(Cc2cccc(OCc3ccccc3)c2)c(N)n1 |
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| Structure | 
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