| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cysteinyl leukotriene receptor 1/2 |
|---|
| Ligand | BDBM50021024 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_52210 (CHEMBL876700) |
|---|
| Ki | 2007±n/a nM |
|---|
| Citation |  Perchonock, CD; Uzinskas, I; McCarthy, ME; Erhard, KF; Gleason, JG; Wasserman, MA; Muccitelli, RM; DeVan, JF; Tucker, SS; Vickery, LM Synthesis and structure-activity relationship studies of a series of 5-aryl-4,6-dithianonanedioic acids and related compounds: a novel class of leukotriene antagonists. J Med Chem29:1442-52 (1986) [PubMed] |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cysteinyl leukotriene receptor 1/2 |
|---|
| Name: | Cysteinyl leukotriene receptor 1/2 |
|---|
| Synonyms: | Cysteinyl leukotriene receptor |
|---|
| Type: | n/a |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | ASSAY_ID of ChEMBL is 98640 |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Cysteinyl leukotriene receptor 1 |
|---|
| Synonyms: | CLTR1_HUMAN | CYSLT1 | CYSLTR1 | Cysteinyl leukotriene D4 receptor | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 1 | HG55 | HMTMF81 | LTD4 receptor | Leukotriene Cysteinyl 1 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 38565.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Leukotriene Cysteinyl 1 CYSLTR1 HUMAN::Q9Y271 |
|---|
| Residue: | 337 |
|---|
| Sequence: | MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIKTYHKKSAFQV
YMINLAVADLLCVCTLPLRVVYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFF
RCIAIVFPVQNINLVTQKKARFVCVGIWIFVILTSSPFLMAKPQKDEKNNTKCFEPPQDN
QTKNHVLVLHYVSLFVGFIIPFVIIIVCYTMIILTLLKKSMKKNLSSHKKAIGMIMVVTA
AFLVSFMPYHIQRTIHLHFLHNETKPCDSVLRMQKSVVITLSLAASNCCFDPLLYFFSGG
NFRKRLSTFRKHSLSSVTYVPRKKASLPEKGEEICKV
|
|
|
|---|
| Component 2 |
| Name: | Cysteinyl leukotriene receptor 2 |
|---|
| Synonyms: | CLTR2_HUMAN | CYSLT2 | CYSLT2R | CYSLTR2 | Cysteinyl leukotriene receptor | Cysteinyl leukotriene receptor 2 | Leukotriene Cysteinyl 2 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 39657.52 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Leukotriene Cysteinyl 2 CYSLTR2 HUMAN::Q9NS75 |
|---|
| Residue: | 346 |
|---|
| Sequence: | MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSI
YVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYV
NMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQ
NGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRV
SHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACF
NPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV
|
|
|
|---|
| BDBM50021024 |
|---|
| n/a |
|---|
| Name | BDBM50021024 |
|---|
| Synonyms: | 7-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydroxy-propoxy]-4-oxo-8-propyl-4H-chromene-2-sodium carboxylate(FPL 55712) | CHEMBL267976 | Sodium; 7-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydroxy-propoxy]-4-oxo-8-propyl-4H-chromene-2-carboxylate | Sodium; 7-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydroxy-propoxy]-4-oxo-8-propyl-4H-chromene-2-carboxylate (FPL 55712) | Sodium; 7-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-2-hydroxy-propoxy]-4-oxo-8-propyl-4H-chromene-2-carboxylate(FPL-55712) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H29O9 |
|---|
| Mol. Mass. | 497.5143 |
|---|
| SMILES | CCCc1c(OCC(O)COc2ccc3c(oc(cc3=O)C([O-])=O)c2CCC)ccc(C(C)=O)c1O |
|---|
| Structure | 
|
|---|
Search and Browse
