| Reaction Details |
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 | Report a problem with these data |
| Target | Glycine receptor subunit alpha-3 |
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| Ligand | BDBM50229711 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEBML_1644301 |
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| EC50 | 450±n/a nM |
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| Citation |  Bregman, H; Simard, JR; Andrews, KL; Ayube, S; Chen, H; Gunaydin, H; Guzman-Perez, A; Hu, J; Huang, L; Huang, X; Krolikowski, PH; Lehto, SG; Lewis, RT; Michelsen, K; Pegman, P; Plant, MH; Shaffer, PL; Teffera, Y; Yi, S; Zhang, M; Gingras, J; DiMauro, EF The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors. J Med Chem60:1105-1125 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycine receptor subunit alpha-3 |
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| Name: | Glycine receptor subunit alpha-3 |
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| Synonyms: | GLRA3 | GLRA3_HUMAN | Glycine receptor alpha-3/beta |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53809.29 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_967474 |
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| Residue: | 464 |
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| Sequence: | MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDAR
IRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDP
SMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPM
DVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKF
TCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQS
SGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEA
FALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKV
FIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
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| BDBM50229711 |
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| n/a |
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| Name | BDBM50229711 |
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| Synonyms: | CHEMBL4074873 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H17N3O4S |
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| Mol. Mass. | 383.421 |
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| SMILES | [H][C@@]12CN(C[C@]1([H])c1cnccc1N(C)C2=O)S(=O)(=O)c1ccc2occc2c1 |r| |
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| Structure | 
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