| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glycine receptor subunit alpha-3 |
|---|
| Ligand | BDBM50229713 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEBML_1644302 |
|---|
| Kd | >20000±n/a nM |
|---|
| Citation |  Bregman, H; Simard, JR; Andrews, KL; Ayube, S; Chen, H; Gunaydin, H; Guzman-Perez, A; Hu, J; Huang, L; Huang, X; Krolikowski, PH; Lehto, SG; Lewis, RT; Michelsen, K; Pegman, P; Plant, MH; Shaffer, PL; Teffera, Y; Yi, S; Zhang, M; Gingras, J; DiMauro, EF The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors. J Med Chem60:1105-1125 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glycine receptor subunit alpha-3 |
|---|
| Name: | Glycine receptor subunit alpha-3 |
|---|
| Synonyms: | GLRA3 | GLRA3_HUMAN | Glycine receptor alpha-3/beta |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 53809.29 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_967474 |
|---|
| Residue: | 464 |
|---|
| Sequence: | MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDAR
IRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDP
SMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPM
DVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKF
TCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQS
SGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEA
FALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKV
FIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
|
|
|
|---|
| BDBM50229713 |
|---|
| n/a |
|---|
| Name | BDBM50229713 |
|---|
| Synonyms: | CHEMBL4081234 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H19N3O5S |
|---|
| Mol. Mass. | 401.436 |
|---|
| SMILES | [H][C@]12CN([C@H](C)[C@@]1([H])C(=O)N(C)c1ccncc21)S(=O)(=O)c1ccc2OCOc2c1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
