| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
|---|
| Ligand | BDBM50231803 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1645572 (CHEMBL3994501) |
|---|
| EC50 | 3487±n/a nM |
|---|
| Citation |  Li, L; Jiang, X; Huang, S; Ying, Z; Zhang, Z; Pan, C; Li, S; Wang, X; Zhang, Z Discovery of Highly Potent 2-Sulfonyl-Pyrimidinyl Derivatives for Apoptosis Inhibition and Ischemia Treatment. ACS Med Chem Lett8:407-412 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
|---|
| Name: | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
|---|
| Synonyms: | 1.3.5.1 | Iron-sulfur subunit of complex II | SDH | SDH1 | SDHB | SDHB_HUMAN | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 31643.02 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_117429 |
|---|
| Residue: | 280 |
|---|
| Sequence: | MAAVVALSLRRRLPATTLGGACLQASRGAQTAAATAPRIKKFAIYRWDPDKAGDKPHMQT
YEVDLNKCGPMVLDALIKIKNEVDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTN
LNKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKL
DGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSL
YRCHTIMNCTRTCPKGLNPGKAIAEIKKMMATYKEKKASV
|
|
|
|---|
| BDBM50231803 |
|---|
| n/a |
|---|
| Name | BDBM50231803 |
|---|
| Synonyms: | CHEMBL4096202 | US11725000, Compound 47 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C13H11F3N2O2S |
|---|
| Mol. Mass. | 316.299 |
|---|
| SMILES | Cc1cccc(c1)-c1cc(nc(n1)S(C)(=O)=O)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
