Reaction Details |
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Target | Amine oxidase [flavin-containing] B |
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Ligand | BDBM50046881 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1647767 (CHEMBL3996823) |
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IC50 | 708±n/a nM |
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Citation | Tzvetkov, NT; Stammler, HG; Neumann, B; Hristova, S; Antonov, L; Gastreich, M Crystal structures, binding interactions, and ADME evaluation of brain penetrant N-substituted indazole-5-carboxamides as subnanomolar, selective monoamine oxidase B and dual MAO-A/B inhibitors. Eur J Med Chem127:470-492 (2017) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Amine oxidase [flavin-containing] B |
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Name: | Amine oxidase [flavin-containing] B |
Synonyms: | AOFB_RAT | Amine oxidase (flavin-containing) B | Amine oxidase [flavin-containing] B | Maob | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B (MAO-B) | Monoamine oxidase B (rMAO-B) | Monoamine oxidase type B (MAOB) | Monoamine oxidase-B (MAO-B) |
Type: | Enzyme |
Mol. Mass.: | 58469.65 |
Organism: | Rattus norvegicus (rat) |
Description: | P19643 |
Residue: | 520 |
Sequence: | MSNKCDVIVVGGGISGMAAAKLLHDCGLSVVVLEARDRVGGRTYTIRNKNVKYVDLGGSY
VGPTQNRILRLAKELGLETYKVNEVERLIHFVKGKSYAFRGPFPPVWNPITYLDYNNLWR
TMDEMGQEIPSDAPWKAPLAEEWDYMTMKELLDKICWTNSTKQIATLFVNLCVTAETHEV
SALWFLWYVKQCGGTTRIISTTNGGQERKFIGGSGQVSERIKDILGDRVKLERPVIHIDQ
TGENVVVKTLNHEIYEAKYVISAIPPVLGMKIHHSPPLPILRNQLITRVPLGSVIKCMVY
YKEPFWRKKDFCGTMVIEGEEAPIAYTLDDTKPDGSCAAIMGFILAHKARKLVRLTKEER
LRKLCELYAKVLNSQEALQPVHYEEKNWCEEQYSGGCYTAYFPPGILTQYGRVLRQPVGK
IFFAGTETASHWSGYMEGAVEAGERAAREILHAIGKIPEDEIWQPEPESVDVPARPITNT
FLERHLPSVPGLLKLLGLTTILSATALGFLAHKKGLFVRF
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BDBM50046881 |
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n/a |
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Name | BDBM50046881 |
Synonyms: | CHEMBL3319245 |
Type | Small organic molecule |
Emp. Form. | C14H11N3O |
Mol. Mass. | 237.2566 |
SMILES | O=C(Nc1ccccc1)c1ccc2[nH]ncc2c1 |
Structure |
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