| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50235684 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1657657 (CHEMBL4007127) |
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| Ki | 740±n/a nM |
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| Citation |  Fares, M; Eladwy, RA; Nocentini, A; El Hadi, SRA; Ghabbour, HA; Abdel-Megeed, A; Eldehna, WM; Abdel-Aziz, HA; Supuran, CT Synthesis of bulky-tailed sulfonamides incorporating pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-1(5H)-yl) moieties and evaluation of their carbonic anhydrases I, II, IV and IX inhibitory effects. Bioorg Med Chem25:2210-2217 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50235684 |
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| n/a |
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| Name | BDBM50235684 |
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| Synonyms: | CHEMBL4100795 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H21ClN6O5S |
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| Mol. Mass. | 601.032 |
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| SMILES | COc1ccc(cc1)-c1cc(nc2nc3n(nc(C(C)=O)n3c(=O)c12)-c1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1 |
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| Structure | 
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