| Reaction Details |
|---|
 | Report a problem with these data |
| Target | ATP-dependent RNA helicase DHX29 |
|---|
| Ligand | BDBM50235738 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1657829 (CHEMBL4007299) |
|---|
| IC50 | >30000±n/a nM |
|---|
| Citation |  Ito, M; Iwatani, M; Kamada, Y; Sogabe, S; Nakao, S; Tanaka, T; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Discovery of selective ATP-competitive eIF4A3 inhibitors. Bioorg Med Chem25:2200-2209 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| ATP-dependent RNA helicase DHX29 |
|---|
| Name: | ATP-dependent RNA helicase DHX29 |
|---|
| Synonyms: | DDX29 | DEAH box protein 29 | DHX29 | DHX29_HUMAN | Nucleic acid helicase DDXx |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 155255.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q7Z478 |
|---|
| Residue: | 1369 |
|---|
| Sequence: | MGGKNKKHKAPAAAVVRAAVSASRAKSAEAGIAGEAQSKKPVSRPATAAAAAAGSREPRV
KQGPKIYSFNSTNDSSGPANLDKSILKVVINNKLEQRIIGVINEHKKQNNDKGMISGRLT
AKKLQDLYMALQAFSFKTKDIEDAMTNTLLYGGDLHSALDWLCLNLSDDALPEGFSQEFE
EQQPKSRPKFQSPQIQATISPPLQPKTKTYEEDPKSKPKKEEKNMEVNMKEWILRYAEQQ
NEEEKNENSKSLEEEEKFDPNERYLHLAAKLLDAKEQAATFKLEKNKQGQKEAQEKIRKF
QREMETLEDHPVFNPAMKISHQQNERKKPPVATEGESALNFNLFEKSAAATEEEKDKKKE
PHDVRNFDYTARSWTGKSPKQFLIDWVRKNLPKSPNPSFEKVPVGRYWKCRVRVIKSEDD
VLVVCPTILTEDGMQAQHLGATLALYRLVKGQSVHQLLPPTYRDVWLEWSDAEKKREELN
KMETNKPRDLFIAKLLNKLKQQQQQQQQHSENKRENSEDPEESWENLVSDEDFSALSLES
ANVEDLEPVRNLFRKLQSTPKYQKLLKERQQLPVFKHRDSIVETLKRHRVVVVAGETGSG
KSTQVPHFLLEDLLLNEWEASKCNIVCTQPRRISAVSLANRVCDELGCENGPGGRNSLCG
YQIRMESRACESTRLLYCTTGVLLRKLQEDGLLSNVSHVIVDEVHERSVQSDFLLIILKE
ILQKRSDLHLILMSATVDSEKFSTYFTHCPILRISGRSYPVEVFHLEDIIEETGFVLEKD
SEYCQKFLEEEEEVTINVTSKAGGIKKYQEYIPVQTGAHADLNPFYQKYSSRTQHAILYM
NPHKINLDLILELLAYLDKSPQFRNIEGAVLIFLPGLAHIQQLYDLLSNDRRFYSERYKV
IALHSILSTQDQAAAFTLPPPGVRKIVLATNIAETGITIPDVVFVIDTGRTKENKYHESS
QMSSLVETFVSKASALQRQGRAGRVRDGFCFRMYTRERFEGFMDYSVPEILRVPLEELCL
HIMKCNLGSPEDFLSKALDPPQLQVISNAMNLLRKIGACELNEPKLTPLGQHLAALPVNV
KIGKMLIFGAIFGCLDPVATLAAVMTEKSPFTTPIGRKDEADLAKSALAMADSDHLTIYN
AYLGWKKARQEGGYRSEITYCRRNFLNRTSLLTLEDVKQELIKLVKAAGFSSSTTSTSWE
GNRASQTLSFQEIALLKAVLVAGLYDNVGKIIYTKSVDVTEKLACIVETAQGKAQVHPSS
VNRDLQTHGWLLYQEKIRYARVYLRETTLITPFPVLLFGGDIEVQHRERLLSIDGWIYFQ
APVKIAVIFKQLRVLIDSVLRKKLENPKMSLENDKILQIITELIKTENN
|
|
|
|---|
| BDBM50235738 |
|---|
| n/a |
|---|
| Name | BDBM50235738 |
|---|
| Synonyms: | Hippuristanol |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H46O5 |
|---|
| Mol. Mass. | 462.6618 |
|---|
| SMILES | [H][C@]12C[C@@]3([H])[C@]4([H])CC[C@@]5([H])C[C@H](O)CC[C@]5(C)[C@@]4([H])[C@@H](O)C[C@]3(C)[C@@]1([H])[C@@](C)(O)[C@]1(C[C@H](C)C(C)(C)O1)O2 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
