| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic initiation factor 4A-III |
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| Ligand | BDBM50235791 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1657827 (CHEMBL4007297) |
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| IC50 | >100000±n/a nM |
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| Citation |  Ito, M; Iwatani, M; Kamada, Y; Sogabe, S; Nakao, S; Tanaka, T; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Discovery of selective ATP-competitive eIF4A3 inhibitors. Bioorg Med Chem25:2200-2209 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic initiation factor 4A-III |
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| Name: | Eukaryotic initiation factor 4A-III |
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| Synonyms: | ATP-dependent RNA helicase DDX48 | ATP-dependent RNA helicase eIF4A-3 | DDX48 | DEAD box protein 48 | EIF4A3 | Eukaryotic initiation factor 4A-like NUK-34 | Eukaryotic translation initiation factor 4A isoform 3 | IF4A3_HUMAN | KIAA0111 | NMP 265 | Nuclear matrix protein 265 | eIF-4A-III | eIF4A-III | hNMP 265 |
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| Type: | Protein |
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| Mol. Mass.: | 46871.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P38919 |
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| Residue: | 411 |
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| Sequence: | MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEK
PSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAV
QIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRA
IKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRIL
VKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREA
NFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNREL
YIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
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| BDBM50235791 |
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| n/a |
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| Name | BDBM50235791 |
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| Synonyms: | CHEMBL4084655 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H14N2O |
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| Mol. Mass. | 202.2524 |
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| SMILES | CC(C)c1ccc2cc([nH]c2c1)C(N)=O |
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| Structure | 
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