| Reaction Details |
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 | Report a problem with these data |
| Target | Acid ceramidase |
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| Ligand | BDBM50238559 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1663372 (CHEMBL4013053) |
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| IC50 | 68±n/a nM |
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| Citation |  Ortega, JA; Arencibia, JM; La Sala, G; Borgogno, M; Bauer, I; Bono, L; Braccia, C; Armirotti, A; Girotto, S; Ganesan, A; De Vivo, M Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells. J Med Chem60:5800-5815 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Acid ceramidase |
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| Name: | Acid ceramidase |
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| Synonyms: | ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC) |
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| Type: | Enzyme |
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| Mol. Mass.: | 44662.65 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13510 |
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| Residue: | 395 |
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| Sequence: | MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYK
RWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIA
AVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITE
QLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWI
LGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKE
SLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLST
KPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
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| BDBM50238559 |
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| n/a |
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| Name | BDBM50238559 |
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| Synonyms: | CHEMBL4090927 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16N4O |
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| Mol. Mass. | 280.3244 |
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| SMILES | Cc1ccccc1CNC(=O)n1c(N)nc2ccccc12 |
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| Structure | 
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