| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-U receptor 2 |
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| Ligand | BDBM50238693 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1664052 (CHEMBL4013733) |
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| EC50 | 0.470000±n/a nM |
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| Citation |  Kanematsu-Yamaki, Y; Nishizawa, N; Kaisho, T; Nagai, H; Mochida, T; Asakawa, T; Inooka, H; Dote, K; Fujita, H; Matsumiya, K; Hirabayashi, H; Sakamoto, J; Ohtaki, T; Takekawa, S; Asami, T Potent Body Weight-Lowering Effect of a Neuromedin U Receptor 2-selective PEGylated Peptide. J Med Chem60:6089-6097 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-U receptor 2 |
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| Name: | Neuromedin-U receptor 2 |
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| Synonyms: | G-protein coupled receptor FM-4 | G-protein coupled receptor TGR-1 | NMU-R2 | NMU2R | NMU2R | NMUR2 | NMUR2_HUMAN | Neuromedin-U receptor 2 | TGR1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 47710.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103075 |
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| Residue: | 415 |
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| Sequence: | MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGV
IGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCY
FKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLP
NTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMA
LRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSES
LAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPA
QRNIFLTECHFVELTEDIGPQFPCQSSMHNSHLPAALSSEQMSRTNYQSFHFNKT
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| BDBM50238693 |
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| n/a |
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| Name | BDBM50238693 |
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| Synonyms: | CHEMBL4063830 |
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| Type | Small organic molecule |
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| Emp. Form. | C57H89N17O11 |
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| Mol. Mass. | 1188.4239 |
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| SMILES | CC(C)C[C@H](NC(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r| |
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| Structure | 
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