| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase A |
|---|
| Ligand | BDBM50580 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1664729 (CHEMBL4014525) |
|---|
| IC50 | 850±n/a nM |
|---|
| Citation |  Wang, S; Xu, L; Lu, YT; Liu, YF; Han, B; Liu, T; Tang, J; Li, J; Wu, J; Li, JY; Yu, LF; Yang, F Discovery of benzofuran-3(2H)-one derivatives as novel DRAK2 inhibitors that protect islet?-cells from apoptosis. Eur J Med Chem130:195-208 (2017) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase A |
|---|
| Name: | Aurora kinase A |
|---|
| Synonyms: | AIK | AIRK1 | ARK-1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK15 GN | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | Serine/threonine-protein kinase aurora-A | Synonyms=AIK | aurora-2 | hARK1 |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 45830.98 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O14965 |
|---|
| Residue: | 403 |
|---|
| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRIPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
|
|
|
|---|
| BDBM50580 |
|---|
| n/a |
|---|
| Name | BDBM50580 |
|---|
| Synonyms: | (2Z)-2-(3,4-dihydroxybenzylidene)-6-hydroxy-coumaran-3-one | (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-1-benzofuran-3-one | (2Z)-2-[(3,4-dihydroxyphenyl)methylidene]-6-hydroxy-3-benzofuranone | (2Z)-2-[[3,4-bis(oxidanyl)phenyl]methylidene]-6-oxidanyl-1-benzofuran-3-one | MLS000863576 | SMR000440743 | SULFURETIN | cid_5281295 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H10O5 |
|---|
| Mol. Mass. | 270.2369 |
|---|
| SMILES | Oc1ccc2C(=O)\C(Oc2c1)=C\c1ccc(O)c(O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
