| Reaction Details |
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 | Report a problem with these data |
| Target | Substance-K receptor |
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| Ligand | BDBM50175494 |
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| Substrate/Competitor | n/a |
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| Ki | 711±n/a nM |
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| Comments | PDSP_1174 |
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| Citation |  Kudlacz, EM; Shatzer, SA; Knippenberg, RW; Logan, DE; Poirot, M; van Giersbergen, PL; Burkholder, TP In vitro and in vivo characterization of MDL 105,212A, a nonpeptide NK-1/NK-2 tachykinin receptor antagonist. J Pharmacol Exp Ther277:840-51 (1996) [PubMed] |
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| More Info.: | Get all data from this article |
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| Substance-K receptor |
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| Name: | Substance-K receptor |
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| Synonyms: | NK2R_MESAU | Neurokinin 2 receptor | Neurokinin NK2 | TAC2R | TACR2 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43436.75 |
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| Organism: | HAMSTER |
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| Description: | P51144 |
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| Residue: | 384 |
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| Sequence: | MGGRAIVTDTNIFSGLESNTTGVTAFSMPAWQLALWATAYLGLVLVAVTGNATVIWIILA
HERMRTVTNYFIINLALADLCMAAFNATFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPITKATIAGIWLVALALASPQCFYSTITVDQGATK
CVVAWPNDNGGKMLLLYHLVVFVLVYFLPLVVMFVAYSVIGLTLWKRAVPRHQAHGANLR
HLHAKKKFVKAMVLVVLTFAICWLPYHLYFILGSFQKDIYYRKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTRTPSLSRRVNRCHTKETLFMT
ADMTHSEATNGQVGSPQDVEPAAP
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| BDBM50175494 |
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| n/a |
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| Name | BDBM50175494 |
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| Synonyms: | 1-{2-[(R)-3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzoyl)-pyrrolidin-3-yl]-ethyl}-4-phenyl-piperidine-4-carboxylic acid amide | 3-((E)-3-Carboxy-3-phenyl-allyl)-4,6-dichloro-1H-indole-2-carboxylic acid | CHEMBL330366 | MDL 104,335 (S)-enantiomer | MDL-105212 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H39Cl2N3O5 |
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| Mol. Mass. | 640.597 |
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| SMILES | COc1cc(cc(OC)c1OC)C(=O)N1CC[C@@](CCN2CCC(CC2)(C(N)=O)c2ccccc2)(C1)c1ccc(Cl)c(Cl)c1 |
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| Structure | 
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